What is the clinical evidence from this study?

Study design: Review. Population: Myocardial infarction. Intervention: Acute myocardial infarction vs. Baseline. Primary outcome: Lipid and lipoprotein levels.

What does this research mean for the field?

Acute myocardial infarction induces an acute phase response characterized by substantial reductions in total cholesterol, LDL, and HDL cholesterol and an increase in triglycerides over days 4 to 7, which stabilize by 2 months. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To characterize the kinetic alterations in lipid and lipoprotein profiles induced by the acute phase response following acute myocardial infarction.

September 16, 2026Journal of the American College of CardiologyOpen Access

Myocardial injury: The acute phase response and lipoprotein metabolism

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Key result

AMI induces an acute phase response dropping LDL ~48% by days 4 to 7.

Authors

RRRobert S. RosensonMount Sinai Health System

Discussion

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Implication

Observational analysis reveals transient lipid and lipoprotein reductions after acute myocardial infarction, indicating post-infarction dyslipidemia screening requires delayed evaluation.

Key Points

To characterize the kinetic alterations in lipid and lipoprotein profiles induced by the acute phase response following acute myocardial infarction.
Monitored circulating lipid and lipoprotein concentrations beginning 24 to 48 hours after the onset of acute myocardial infarction chest pain.
Tracked temporal changes in total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels through 2 months post-event.
Total cholesterol reached a nadir 47% below baseline on days 4 to 5, while LDL cholesterol and HDL cholesterol reached nadirs 48% and 32% below baseline, respectively, on day 7.
Triglyceride levels increased to a maximal concentration 58% above baseline on day 7 post-infarction.
Lipid and lipoprotein alterations stabilized to baseline levels by approximately 2 months after the acute cardiac event.

PICO

Population

Myocardial infarction

Exposure / Comparator

Acute myocardial infarction vs Baseline

Primary Outcome

Lipid and lipoprotein levels

Cite This Study

Robert S. Rosenson (1993) conducted a review in Myocardial infarction. Acute myocardial infarction vs. Baseline was evaluated on Lipid and lipoprotein levels. Acute myocardial infarction induces an acute phase response with maximal reductions in total cholesterol (47%), LDL (48%), and HDL (32%), and a 58% increase in triglycerides by days 4 to 7.

synapsesocial.com/papers/6aaa5e58c0c5ec5c126fa6fd https://doi.org/10.1016/0735-1097(93)90213-k

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Implication

Observational analysis reveals transient lipid and lipoprotein reductions after acute myocardial infarction, indicating post-infarction dyslipidemia screening requires delayed evaluation.

Myocardial injury: The acute phase response and lipoprotein metabolism

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Myocardial injury: The acute phase response and lipoprotein metabolism

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Also Consider

Also Consider