Key result
Acute myocardial infarction was associated with significant reductions in total cholesterol, LDL, and HDL, and increases in triglycerides and inflammatory markers between day 1 and day 2.
Why the study?
How do lipid profiles and inflammatory markers change serially within the first 7 days following an acute myocardial infarction?
Observational (n=550)
No
How do lipid profiles and inflammatory markers change serially within the first 7 days following an acute myocardial infarction?
Absolute Event Rate: 161.68% vs 174.81%
p-value: p=<0.001
Significant fluctuations in lipid profiles and inflammatory markers occur within the first 7 days post-AMI, reinforcing the clinical recommendation to assess baseline lipids within 24 hours of admission to accurately guide lipid-lowering therapy.
Post-AMI lipid fluctuations warrant caution in measurement timing; leaves open whether early assessment improves outcomes in prospective trials.
Serum concentration of lipids and lipoproteins changes during the course of acute coronary syndrome as a consequence of the inflammatory response. The objective of this study was to evaluate the effect of acute myocardial infarction (AMI) on the levels of lipid profile and inflammatory markers. We investigated 400 patients with AMI who were admitted within 24 h of onset of symptoms. Serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) were determined by standard enzymatic methods along with high sensitive C-reactive protein (hs-CRP) (latex enhanced immunoturbidimetric assay) and cytokines, interleukin (IL)-6 and IL-10 (quantitative ''sandwich'' enzyme-linked immunosorbent assay). The results indicate a trend of reduced TC, LDL, and HDL, and elevated TG levels, along with pro- and anti-inflammatory markers (p < 0.001), between day 1 and the day 2 serum samples of AMI patients. However, corrections in the serum levels have been observed at day 7. Our results demonstrate significant variations in the mean lipid levels and inflammatory markers between days 1, 2 and 7 after AMI. Therefore, it is recommended that the serum lipids should be assessed within 24 hours after infarction. Early treatment of hyperlipidemia provides potential benefits. Exact knowledge regarding baseline serum lipids and lipoprotein levels as well as their varying characteristics can provide a rational basis for clinical decisions about lipid lowering therapy.
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Shrivastava et al. (2015) conducted an observational in Acute myocardial infarction (n=550). Acute myocardial infarction vs. Baseline (Day 1) / Healthy controls was evaluated on Change in serum total cholesterol from day 1 to day 2 post-AMI (mg/dL) (p=<0.001). Acute myocardial infarction was associated with significant reductions in total cholesterol, LDL, and HDL, and increases in triglycerides and inflammatory markers between day 1 and day 2.
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