High-NaCl Diet Aggravates Cardiac Injury in Rats with Adenine-Induced Chronic Renal Failure and Increases Serum Troponin T Levels
Key result
High-NaCl diet worsens arterial pressure, LV fibrosis, and cTnT in rats with chronic renal failure.
- P<0.05
Why the study?
The effects of a high-NaCl diet on left ventricular morphology and serum cardiac troponin T levels in rats with adenine-induced chronic renal failure were not well characterized.
Does a high-NaCl diet aggravate cardiac injury in rats with adenine-induced chronic renal failure?
Population
Male Sprague-Dawley rats with adenine-induced chronic renal failure or pair-fed controls
Comparison
High-NaCl diet (4%) vs normal NaCl diet (0.6%)
Design
Randomized controlled preclinical study
Follow-up
2 weeks
Authors
Discussion
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Implication
Offers a rat model for salt effects on cardiorenal injury; leaves open translation to human CKD management.
Study Design
Type
RCT
Randomization
Randomized
Structured PICO
Does a high-NaCl diet aggravate cardiac injury in rats with adenine-induced chronic renal failure?
P
Population
Male Sprague-Dawley rats with adenine-induced chronic renal failure or controls, randomized to a normal or high-NaCl diet for 2 weeks.
I
Intervention
High-NaCl diet (4%) for 2 weeks
C
Comparator
Normal NaCl diet (0.6%) for 2 weeks
O
Outcome
Left ventricular (LV) morphology and serum levels of cardiac troponin T (cTnT)surrogate
Main Result
p-value: p=<0.05
A high-NaCl diet exacerbates left ventricular injury and increases serum troponin T levels in a rat model of chronic renal failure, providing a potential model for studying renocardiac syndromes.
Cite This Study
Kashioulis et al. (2016) conducted an RCT in Adenine-induced chronic renal failure. High-NaCl diet vs. Normal NaCl diet (0.6%) was evaluated on Left ventricular morphology and serum levels of cardiac troponin T (p=<0.05). Two weeks of a high-NaCl diet in rats with chronic renal failure significantly augmented increases in arterial pressure, LV fibrosis, and serum cTnT levels (P<0.05 for interaction).