Patho-Physiologically Based Logistics for Treatment of Cancer

Analytical modeling and computer simulation may provide an assessment for the success of different cancer therapeutic strategies (both maximum tolerable dosing and metronomic dosing), particularly for the presence of microscopically dormant cells. Different authors substantially showed that metronomic strategy is better than maximum tolerable dosing. In the present work, the different physiological constraints have been considered. Accumulation of drug, dead tumor cells as well as metabolites produced by living tumor cells produce toxicity that affect the physiological system. This affects the subsequent drug application and thereby the therapeutic procedure and its outcome. Translating these into logistics and incorporating them into analytical state-space models, the transformation of the overall system has been examined through computer simulations. The observation is that situations of frequent drug stoppages may occur due to patho-physiological constraints, which may in turn inactivate the cell-mediated immune response. Simulation results suggest that even the combination of different strategies does not improve the situation. Other ways of boosting the immunity and tuning of biological constraints would be required to get positive outcome.