A Case Report of Primary Buttock Angiosarcoma with Lung and Liver Metastases with a Dismal Prognosis

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Primary buttock angiosarcoma with lung and liver metastases (n=1). Intervention: Right portal vein ligation and tumor biopsy. Primary outcome: Clinical outcome.

Q: What does this research mean for the field?

Primary buttock angiosarcoma can exhibit a highly aggressive clinical course with rapid lung and liver metastases, culminating in fatal complications such as liver failure and disseminated intravascular coagulation (DIC) associated with Kasabach-Merritt syndrome. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yume Minagawa; Yohei Ota; Yuko Tamura; Taichi Yabuno; Masazumi Takahashi; Yasuhisa MOCHIZUKI; Kyoko ONO

doi:10.3919/jjsa.82.1898

January 1, 2021Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)Open Access

A Case Report of Primary Buttock Angiosarcoma with Lung and Liver Metastases with a Dismal Prognosis

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Key result

Primary buttock angiosarcoma linked to fatal Kasabach-Merritt syndrome ~56 days after right portal vein ligation.

n=1

Key Points

To describe the clinical progression, diagnostic pitfalls, and surgical management of primary buttock angiosarcoma presenting with sequential pulmonary and hepatic metastases.
Clinical and surgical case evaluation of a 78-year-old female presenting with a buttock mass and subsequent visceral lesions.
Sequential interventions including primary buttock mass resection, partial lung resection, and open right portal vein ligation with biopsy.
Initial histological evaluation of both the resected buttock mass and the enlarging right lower lobe lung nodule mischaracterized the lesions as benign hemangiomas.
A rapidly expanding hepatic mass detected one year post-initial resection required portal vein ligation due to insufficient remnant liver volume, demonstrating aggressive multi-organ metastatic progression.

Study Design

Type

Case Report (n=1)

Structured PICO

P

Population

A 78-year-old woman with primary buttock angiosarcoma who developed lung and liver metastases and died of liver failure and DIC associated with Kasabach-Merritt syndrome.

I

Intervention

Excision of buttock skin tumor, partial lung resection, open right portal vein branch ligation, and tumor biopsy

Case report of a 78-year-old female with primary buttock angiosarcoma presenting with lung and liver metastases.

Limitations

Single case report
Difficult initial diagnosis due to atypical presentation and lack of clear angiosarcoma features in early biopsies

Implication

Warrants caution with portal vein ligation in angiosarcoma with liver metastases; leaves open its safety and KMS triggers in rare sarcomas.

Abstract

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Discussion

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Cite This Study

Minagawa et al. (2021) conducted a case report in Primary buttock angiosarcoma with lung and liver metastases (n=1). Right portal vein ligation and tumor biopsy was evaluated on Clinical outcome. A 78-year-old woman with primary buttock angiosarcoma developed rapid liver and lung metastases, leading to death from liver failure and DIC associated with Kasabach-Merritt syndrome 56 days after right portal vein ligation.

synapsesocial.com/papers/6aaa635e598f2e104f57c613 https://doi.org/10.3919/jjsa.82.1898

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A Case Report of Primary Buttock Angiosarcoma with Lung and Liver Metastases with a Dismal Prognosis

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

A Case Report of Primary Buttock Angiosarcoma with Lung and Liver Metastases with a Dismal Prognosis

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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