Key result
Fetal echocardiography reveals extracardiac anomalies in ~46% of TOF and PA-VSD cases.
Why the study?
The reliability of foetal echocardiography to predict post-natal surgical outcome in fetuses diagnosed with TOF or PA-VSD was uncertain.
Does fetal echocardiography accurately predict post-natal surgical outcomes in fetuses with TOF or PA-VSD?
Population
218 fetuses diagnosed with TOF (n=153) or PA-VSD (n=65)
Comparison
Foetal echocardiographic findings vs post-natal surgical outcomes
Design
Cohort study
Follow-up
First year of life
Authors
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May guide prenatal counseling on anomalies and repair feasibility in TOF/PA-VSD; leaves open prospective validation of PA size thresholds.
Cohort (n=218)
Does fetal echocardiography accurately predict post-natal surgical outcomes in fetuses with TOF or PA-VSD?
Fetal echocardiography can reliably predict the likelihood of complete repair in the first year of life for fetuses with TOF and PA-VSD based on pulmonary artery size and main pulmonary trunk presence.
Kaguelidou et al. (2008) conducted a cohort in Tetralogy of Fallot or pulmonary atresia with ventricular septal defect (n=218). Foetal echocardiographic assessment was evaluated on Post-natal surgical outcome (complete repair in the first year of life) and pregnancy outcome. Foetal echocardiographic assessment of TOF and PA-VSD revealed extracardiac anomalies in 46% of cases and led to pregnancy termination in 34%, while pre-natal PA size predicted complete repair.
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