What does this research mean for the field?

Ethanol extracts of Waltheria indica aerial parts harvested in winter exhibit superior analgesic and anti-inflammatory activity compared to those harvested in summer. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To examine the influence of seasonal changes on the phytochemical profile, analgesic effects, and anti-inflammatory activity of ethanol extracts from the aerial parts of Waltheria indica L. in rodents.

January 2, 2025Asian Journal of Biological SciencesOpen Access

Impact of Seasonal Changes on the Phytochemical Composition, Analgesic and Anti-Inflammatory Properties of Ethanol Extract from the Aerial Parts of Waltheria indica L. in Rodents

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Authors

LHLawan Jabba HamiduBaze University IDIgbayilola Yusuff DimejiUniversidade Federal de Pernambuco AMA. S. MujtabaBaze University

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Implication

Preclinical study reveals superior analgesic and anti-inflammatory activity in winter-harvested Waltheria indica in rodents, suggesting winter as the optimal harvesting season.

Key Points

To examine the influence of seasonal changes on the phytochemical profile, analgesic effects, and anti-inflammatory activity of ethanol extracts from the aerial parts of Waltheria indica L. in rodents.
Aerial parts of Waltheria indica were collected during the wet and dry seasons and subjected to ethanol extraction and spectrophotometric phytochemical quantification.
Analgesic and anti-inflammatory effects were assessed in rodent models using acetic acid-induced writhing in mice and carrageenan-induced paw edema in rats across doses of 200 and 400 mg/kg.
At doses of 200 and 400 mg/kg, the summer extract significantly reduced acetic acid-induced writhing in mice by 48.05% and 57.41%, respectively, compared to controls (p < 0.05).
At 400 mg/kg, paw edema reduction 4 hours post-carrageenan injection was 79.60% for the winter extract versus 64.52% for the summer extract, with the winter extract showing significantly higher inhibition (p < 0.05).

Cite This Study

Hamidu et al. (2025) studied this question.

synapsesocial.com/papers/6aaa6686c85bdfeaa654d127 https://doi.org/10.3923/ajbs.2025.288.299

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Implication

Preclinical study reveals superior analgesic and anti-inflammatory activity in winter-harvested Waltheria indica in rodents, suggesting winter as the optimal harvesting season.

Impact of Seasonal Changes on the Phytochemical Composition, Analgesic and Anti-Inflammatory Properties of Ethanol Extract from the Aerial Parts of Waltheria indica L. in Rodents

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Key Points

Cite This Study

Impact of Seasonal Changes on the Phytochemical Composition, Analgesic and Anti-Inflammatory Properties of Ethanol Extract from the Aerial Parts of Waltheria indica L. in Rodents

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Key Points

Cite This Study

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