Key result
Active acute lymphoblastic leukemia is linked to severe dyslipidemia that normalizes during remission.
Why the study?
Lipid abnormalities may be involved in oncogenesis, but serum lipid alterations in childhood ALL at diagnosis and remission were not well characterized.
Do serum lipid levels alter at diagnosis and during remission in children with acute lymphoblastic leukemia?
Cohort (n=64)
Do serum lipid levels alter at diagnosis and during remission in children with acute lymphoblastic leukemia?
Children with ALL exhibit significant but reversible lipid abnormalities at diagnosis, which normalize during remission.
Epidemiologic studies have indicated a relationship between serum lipids and cancer, and it is possible that lipid abnormalities are involved in the mechanism of oncogenesis. This study was performed to investigate serum lipid alterations in patients with acute lymphoblastic leukemia (ALL) at diagnosis and during remission of the disease. Plasma lipids and lipoproteins were measured at diagnosis, prior to the administration of induction treatment, and every 2 months for the first 12 months of the maintenance phase of chemotherapy in 64 patients with ALL. Nearly all patients demonstrated a predictable pattern of serum lipid alterations that consisted of extremely low levels of high-density lipoprotein cholesterol, elevated triglycerides, and elevated low-density lipoprotein cholesterol. Patients studied again during remission demonstrated a return to normal values, and the difference was statistically significant. The results suggest that at diagnosis of ALL an abnormality in lipid metabolism is present, which is reversed during remission.
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Moschovi et al. (2004) conducted a cohort in Acute lymphoblastic leukemia (ALL) (n=64). Active acute lymphoblastic leukemia vs. Remission was evaluated on Plasma lipids and lipoproteins. Active acute lymphoblastic leukemia was associated with extremely low HDL, elevated triglycerides, and elevated LDL, which significantly returned to normal values during remission.
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