Key result
Metformin treatment linked to improved aortic wave reflection in overweight and obese women with PCOS.
Why the study?
Conflicting findings have been published regarding pressure wave reflection and arterial stiffness in young women with PCOS.
Does metformin improve aortic wave reflection and endothelial function in lean and obese women with polycystic ovary syndrome?
Observational (n=64)
Does metformin improve aortic wave reflection and endothelial function in lean and obese women with polycystic ovary syndrome?
Metformin treatment for 6 months improves aortic wave reflection in overweight/obese women with PCOS and endothelial function in both lean and obese PCOS women, highlighting its potential cardiovascular benefits.
Answers are grounded in this paper and cite their sources.
May support vascular assessment in obese PCOS; hypothesis-generating and requires randomized confirmation before practice change.
L'évaluation de la réflexion des ondes aortiques chez des femmes maigres et obèses avec le syndrome des ovaires polykystiquesIntroduction.Des résultats contradictoires ont été publiés concernant la réflexion des ondes de pression et la raideur artérielle chez les jeunes femmes atteintes du syndrome des ovaires polykystiques (SOPK), par opposition à la présence ab initio manifeste de la dysfonction ABSTRACT Introduction.Conflicting findings have been published regarding the pressure wave reflection and the arterial stiffness in young women with polycystic ovary syndrome (PCOS) as opposed to the overt ab initio presence of endothelial dysfunction, which can be reversed six months after metformin administration.The aim of this study was to investigate wave reflections in women with PCOS and to evaluate the effect of metformin treatment.
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Alexandraki et al. (2020) conducted an observational in Polycystic ovary syndrome (n=64). Metformin vs. Baseline (pre-treatment) was evaluated on Augmentation Index corrected for heart rate 75 bpm (AIx@75) in overweight/obese PCOS women (p=0.046). Metformin treatment (1700 mg/daily for 6 months) significantly improved aortic wave reflection (AIx@75) in overweight and obese women with polycystic ovary syndrome (p=0.046).
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