Key result
AV node radiation ≥6.83 Gy linked to ~349% greater risk of acute LV strain alterations post-radiotherapy.
Why the study?
The spatial dosimetric relationships between cardiac substructures and hyper-acute subclinical myocardial strain alterations after thoracic radiotherapy were not well characterized.
Does specific cardiac substructure radiation dosimetry predict acute subclinical myocardial strain alterations in patients undergoing thoracic radiotherapy?
Cohort (n=40)
No
Does specific cardiac substructure radiation dosimetry predict acute subclinical myocardial strain alterations in patients undergoing thoracic radiotherapy?
Odds Ratio: 4.49 (95% CI 3.46–5.82)
Absolute Event Rate: 58.3% vs 12.5%
p-value: p=<0.001
Specific radiation dose thresholds to cardiac substructures (AVN, SAN, RCA) strongly predict hyper-acute subclinical myocardial strain alterations, highlighting the need for precision substructure sparing in thoracic radiotherapy.
Hyper-acute strain changes after thoracic IMRT may link to substructure doses; leaves open clinical relevance pending larger outcome trials.
Purpose To evaluate the spatial dosimetric relationships between cardiac substructures and hyper-acute subclinical myocardial strain alterations after thoracic intensity-modulated radiotherapy (IMRT). Methods Forty patients with thoracic malignancies were prospectively enrolled. Two-dimensional speckle-tracking echocardiography (2D-STE) was performed at baseline and 1–2 days post-radiotherapy to assess left ventricular global longitudinal strain (LVGLS) and right ventricular free wall longitudinal strain (RVFWLS). Cardiac substructures, including the atrioventricular node (AVN), sinoatrial node (SAN), and right coronary artery (RCA), were contoured standardized. Acute subclinical strain alteration was defined as a ≥ 15% relative reduction from baseline. Optimal dosimetric cutoffs were determined via Maxstat analysis, and independent predictors were identified using multivariable logistic regression. Results Immediately post-radiotherapy, the incidence of hyper-acute subclinical strain alterations was 65% (26/40) for the right ventricle and 40% (16/40) for the left ventricle, captured by 2D-STE prior to any conventional LVEF decline. Multivariable analysis identified AVN D mean ≥ 6.83 Gy as an independent predictor of acute LV strain alterations (OR = 4.49, 95%CI: 3.46–5.82, P < 0.001). For the right ventricle, RCA V 5 ≥ 77.56% (OR = 6.0, 95%CI: 4.26–8.53, P < 0.001), SAN D max ≥ 33.36 Gy (OR = 3.07, 95%CI: 2.11–4.44, P < 0.001) were independent predictors. Conclusion Hyper-acute subclinical strain alterations are highly prevalent immediately after thoracic radiotherapy, with right-sided structures exhibiting enhanced radiosensitivity. Dosimetric metrics of the AVN, SAN, and RCA serve as independent predictors. Although these data-driven cutoffs are exploratory and hypothesis-generating, they suggest that independent sparing of the conduction system and coronary vasculature should be considered in precision radiotherapy, warranting validation in future large-scale, multicenter trials.
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ZHANG et al. (2026) conducted a cohort in Thoracic malignancies (n=40). Atrioventricular node mean radiation dose ≥ 6.83 Gy vs. Atrioventricular node mean radiation dose < 6.83 Gy was evaluated on Acute subclinical left ventricular strain alteration (≥ 15% relative reduction in LVGLS from baseline) (OR 4.49, 95% CI 3.46-5.82, p=<0.001). An atrioventricular node mean radiation dose ≥ 6.83 Gy independently predicted acute subclinical left ventricular strain alterations (OR 4.49) immediately following thoracic radiotherapy.
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