Key result
Infertility treatment linked to ~34% higher risk of hypertensive disorders of pregnancy versus spontaneous conception.
Why the study?
Infertility treatment is a possible factor in hypertensive disorders of pregnancy, and identifying characteristics of women at risk is valuable for prevention and treatment.
Does infertility treatment increase the risk of hypertensive disorders of pregnancy in pregnant women?
Cohort (n=12,456)
Does infertility treatment increase the risk of hypertensive disorders of pregnancy in pregnant women?
Infertility treatment, including IVF/ICSI, is associated with an increased risk of hypertensive disorders of pregnancy, even among women without traditional modifiable risk factors like obesity or smoking.
Answers are grounded in this paper and cite their sources.
May support closer monitoring for hypertensive disorders after infertility treatment; extends observational data but leaves causality unresolved.
Infertility treatment is a possible factor in hypertensive disorders of pregnancy (HDP). Identifying the characteristics of pregnant women who have undergone infertility treatment and have a potential risk for HDP is valuable for its prevention and treatment. Using data from 12,456 pregnant Japanese women from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, the association between infertility treatment and HDP was analyzed. A multiple logistic regression model showed an association between infertility treatment and HDP (odds ratio, 1.34; 95% confidence interval, 1.05–1.72). In vitro fertilization/intracytoplasmic sperm injection were also associated with HDP. Moreover, these associations were observed even among women who were not overweight and did not smoke. The application of infertility treatment should be carefully considered, even among women with low modifiable risk factors.
No takes yet. Share an insight, caveat, or question.
Ishikuro et al. (2023) conducted a cohort in Pregnancy (n=12,456). Infertility treatment vs. Spontaneous pregnancy (no infertility treatment) was evaluated on Hypertensive disorders of pregnancy (HDP) (OR 1.34, 95% CI 1.05-1.72). Infertility treatment was associated with a significantly higher risk of hypertensive disorders of pregnancy compared to spontaneous conception (adjusted OR 1.34).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: