Why the study?
To evaluate the association between prehypertension in early pregnancy, hypertensive disorders of pregnancy, and adverse perinatal outcomes.
Does prehypertension in early pregnancy increase the risk of hypertensive disorders of pregnancy and adverse perinatal outcomes in pregnant women?
Does prehypertension in early pregnancy increase the risk of hypertensive disorders of pregnancy and adverse perinatal outcomes in pregnant women?
Prehypertension in early pregnancy is an independent risk factor for developing hypertensive disorders of pregnancy and adverse perinatal outcomes.
Prehypertension may warrant closer monitoring; hypothesis-generating for risk stratification pending prospective trials.
Objective: We evaluated the association between pre-hypertension (120–139 or 80–89 mmHg) in early pregnancy, hypertensive disorders of pregnancy (HDP), and perinatal adverse outcomes.Methods: We included 14,066 pregnant women, treated between 2003 and 2019 in Japan. Based on a blood pressure chart review recorded before 20 weeks of gestation, we stratified participants into the prehypertension (n = 3,806) and normotensive (n = 10,260) groups.Results: Prehypertension, an independent risk factor for HDP in the multivariate analysis (P< 0.001), was significantly associated with preterm and small-for-gestational age infants.Conclusion: Prehypertension potentially confers a risk for adverse perinatal outcomes in apparently normal pregnancies.
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Nagao et al. (2020) studied this question.
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