Key result
Rivaroxaban is linked to 0% asymptomatic thrombosis versus LMWH after hip arthroplasty in older adults.
Why the study?
The efficacy and safety of rivaroxaban compared to low-molecular-weight heparins for preventing venous thromboembolic complications in elderly patients after hip arthroplasty were evaluated.
Does rivaroxaban prevent venous thromboembolic complications compared to low-molecular-weight heparins in elderly patients after hip arthroplasty?
Cohort (n=94)
Does rivaroxaban prevent venous thromboembolic complications compared to low-molecular-weight heparins in elderly patients after hip arthroplasty?
Absolute Event Rate: 0% vs 2.1%
Rivaroxaban provides effective and safe thromboprophylaxis comparable to low-molecular-weight heparins in elderly patients undergoing hip arthroplasty.
Rivaroxaban showed comparable safety to LMWH in this cohort; leaves open need for RCTs before changing thromboprophylaxis practice in elderly hip arthroplasty.
Results of retrospective analysis of the efficacy and safety of venous thromboembolic complications prevention using anticoagulants (low-molecular-weight heparins and rivaroxaban) in elderly (over 75 years) patients after hip arthroplasty are presented. Ninety four patients were divided into 2 groups (n=47) depending on the applied anticoagulant. Follow up period was 6 months after hospitalization. Asymptomatic thrombosis was diagnosed by duplex ultrasonography only in 1 (2.1%) patient from low-molecular-weight heparin group. No one case of either bleeding or hemorrhage was recorded. It is stated that rivaroxaban ensured effective thromboprophylaxis and safety after hip arthroplasty in elderly patients when no restrictions related to the use of low-molecular-weight heparin injections are present.
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Афанасьев et al. (2016) conducted a cohort in Venous thromboembolic complications after hip arthroplasty (n=94). Rivaroxaban vs. Low-molecular-weight heparins was evaluated on Asymptomatic thrombosis. Rivaroxaban ensured effective thromboprophylaxis and safety after hip arthroplasty in elderly patients, with 0% asymptomatic thrombosis compared to 2.1% with low-molecular-weight heparins.
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