Key result
Rivaroxaban linked to ~0% asymptomatic thrombosis versus LMWH after hip arthroplasty in elderly patients.
Why the study?
The efficacy and safety of rivaroxaban compared to low-molecular-weight heparins for preventing venous thromboembolic complications in elderly patients after hip arthroplasty were evaluated.
Does rivaroxaban prevent venous thromboembolic complications compared to low-molecular-weight heparins in elderly patients over 75 years after hip arthroplasty?
Cohort (n=94)
Does rivaroxaban prevent venous thromboembolic complications compared to low-molecular-weight heparins in elderly patients over 75 years after hip arthroplasty?
Absolute Event Rate: 0% vs 2.1%
Rivaroxaban provides effective and safe venous thromboembolism prophylaxis comparable to low-molecular-weight heparins in elderly patients undergoing hip arthroplasty.
May support rivaroxaban for VTE prophylaxis after hip arthroplasty in elderly; hypothesis-generating and requires randomized confirmation.
Results of retrospective analysis of the efficacy and safety of venous thromboembolic complications prevention using anticoagulants (low-molecular-weight heparins and rivaroxaban) in elderly (over 75 years) patients after hip arthroplasty are presented. Ninety four patients were divided into 2 groups (n=47) depending on the applied anticoagulant. Follow up period was 6 months after hospitalization. Asymptomatic thrombosis was diagnosed by duplex ultrasonography only in 1 (2.1%) patient from low-molecular-weight heparin group. No one case of either bleeding or hemorrhage was recorded. It is stated that rivaroxaban ensured effective thromboprophylaxis and safety after hip arthroplasty in elderly patients when no restrictions related to the use of low-molecular-weight heparin injections are present.
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Афанасьев et al. (2016) conducted a cohort in Hip arthroplasty (n=94). Rivaroxaban vs. Low-molecular-weight heparins was evaluated on Asymptomatic thrombosis diagnosed by duplex ultrasonography. Rivaroxaban ensured effective thromboprophylaxis after hip arthroplasty in elderly patients, with 0% asymptomatic thrombosis compared to 2.1% with low-molecular-weight heparins.
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