Key result
Isoxsuprine improves bursting pressure and hydroxyproline concentration in ischemic rat colon.
Why the study?
The leakage rate of colonic anastomoses can be high and tissue perfusion may be compromised in elderly patients and low colorectal anastomoses, necessitating investigation of agents that improve healing.
Does isoxsuprine improve healing in normal and ischaemic rat colon?
Does isoxsuprine improve healing in normal and ischaemic rat colon?
Isoxsuprine improves bursting pressure and hydroxyproline concentration in ischaemic rat colon, suggesting a potential role in improving healing of poorly perfused colonic anastomoses.
May support exploration of isoxsuprine for ischaemic anastomoses; leaves open translation to human colonic surgery.
The leakage rate of colonic anastomoses may be as high as 13%. A good blood supply is of paramount importance. However tissue perfusion may be at risk in the elderly and in low colorectal anastomoses. We have tested the effect of isoxsuprine, an agent which reduces blood viscosity, and is an alpha-adrenergic antagonist and beta-adrenergic agonist, on the healing process in normal and ischaemic rat colon. Both bursting pressure and hydroxyproline concentration were significantly improved in compromised ischaemic colon in animals treated with isoxsuprine. Isoxsuprine may improve healing in poorly perfused colonic anastomoses.
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Foster et al. (2008) studied Ischaemic colon and colonic anastomoses. Isoxsuprine was evaluated on Bursting pressure and hydroxyproline concentration. Isoxsuprine significantly improved bursting pressure and hydroxyproline concentration in compromised ischaemic rat colon.
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