Answers are grounded in this paper and cite their sources.
Two infants with biliary atresia who exhibited three-fold increased trough levels of tacrolimus and required reduced doses during episodes of acute infantile diarrhea within 5 months of liver transplantation are described. The cause of the increase was not explained simply by hemoconcentration as a result of significant loss of extracellular fluid during these episodes. It does highlight an important issue: that of the continuing need to carefully monitor the trough levels of tacrolimus in such infants.
No takes yet. Share an insight, caveat, or question.
Matsui et al. (1996) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: