Key result
Coronary stenoses of at least 50% linked to ~0.16 g/L higher fibrinogen levels.
Why the study?
The pathogenetic and predictive role of haemostatic factors in the progression of coronary heart disease in patients with angina pectoris was investigated.
Population
3043 patients with angina pectoris undergoing coronary angiography
Comparison
Associations of haemostatic factors with presence and extent of coronary stenoses and other coronary risk factors
Design
European multicentre cross-sectional study
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Higher fibrinogen was associated with significant stenoses in angina; hypothesis-generating and should not change practice without prospective data.
Cross-Sectional (n=3,043)
Yes
Mean Difference: 0.16
p-value: p=< 0.0001
Elevated fibrinogen and depressed fibrinolytic activity are associated with the presence of significant coronary stenoses in patients with angina pectoris.
A 1993 study conducted a cross-sectional in angina pectoris (n=3,043). One or more coronary stenoses of at least 50% vs. No coronary stenoses of at least 50% was evaluated on Fibrinogen levels (MD 0.16 g/L, p=< 0.0001). Patients with one or more coronary stenoses of at least 50% had higher fibrinogen levels by an average of 0.16 g/L compared to those without (P<0.0001).
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