Key result
Brief balloon occlusion elicits greater ST elevation in the LCA versus the RCA.
Why the study?
The relationship between corrected S-T segment elevation and ischemia severity in left versus right coronary artery territories during controlled occlusion was unclear.
Does a 120-s balloon occlusion in the left coronary artery produce different S-T segment elevation compared to the right coronary artery in patients with coronary artery disease?
Observational (n=50)
Does a 120-s balloon occlusion in the left coronary artery produce different S-T segment elevation compared to the right coronary artery in patients with coronary artery disease?
The left coronary artery territory exhibits greater electrocardiographic sensitivity to a brief 2-minute ischemic period than the right coronary artery territory, independent of mass at risk and collateral supply.
Infarct size (IS) increases with vascular occlusion time, area at risk for infarction, lack of collateral supply, absence of preconditioning, and myocardial demand for O2 supply. ECG S-T segment elevation is used as a measure of severity of ischemia and a surrogate for IS. This study in 50 patients with coronary artery disease undergoing a first 120-s balloon occlusion of a stenosis sought to determine whether S-T segment elevation, corrected for the above-mentioned variables, in the left coronary artery (LCA group, n = 36) is different from that in the right coronary artery (RCA group, n = 14) territory. After consideration of all known determinants of IS, particularly mass at risk and collateral supply, the LCA territory is more sensitive than the RCA region to a 2-min period of myocardial ischemia.
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Marchi et al. (2006) conducted an observational in Coronary artery disease (n=50). Left coronary artery (LCA) balloon occlusion vs. Right coronary artery (RCA) balloon occlusion was evaluated on ECG S-T segment elevation. The left coronary artery territory was more sensitive than the right coronary artery region to a 2-minute period of myocardial ischemia during balloon occlusion.
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