Key result
ADIPOR1 and ADIPOR2 gene dysregulation is linked to cancer stemness, tumor immunity, and drug sensitivity.
Why the study?
There is an urgent need to explore the roles of AdipoR1 and AdipoR2 in cancers due to the vital role of adipose tissue in various diseases including cancers.
Observational
ADIPOR1 and ADIPOR2 are dysregulated across multiple cancers and correlate with tumor microenvironment and drug sensitivity, suggesting they may be potential therapeutic targets in oncology.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for ADIPOR1/2 targeting in oncology; leaves open prospective validation before any clinical application.
Introduction: AdipoR1 and AdipoR2 proteins, encoded by ADIPOR1 and ADIPOR2 genes respectively, are the receptors of adiponectin secrected by adipose tissue. Increasing studies have identified the vital role of adipose tissue in various diseases, including cancers. Hence, there is an urgent need to explore the roles of AdipoR1 and AdipoR2 in cancers. Methods: We conducted a comprehensive pan-cancer analysis for the roles of AdipoR1 and AdipoR2 via several public databases, including expression differences, prognostic value, and the correlations with tumor microenvironment, epigenetic modification, and drug sensitivity. Results: Both ADIPOR1 and ADIPOR2 genes are dysregulated in most cancers, but their genomic alteration frequencies are low. In addition, they are also correlated with the prognosis of some cancers. Although they are not strongly correlated with tumor mutation burden (TMB) or microsatellite instability (MSI), ADIPOR1/2 genes display a significant association with cancer stemness, tumor immune microenvironment, immune checkpoint genes (especially CD274 and NRP1), and drug sensitivity. Discussion: ADIPOR1 and ADIPOR2 play critical roles in diverse cancers, and it is a potential strategy to treat tumors through targeting ADIPOR1 and ADIPOR2.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2023) conducted an observational in Cancer. ADIPOR1 and ADIPOR2 expression vs. Normal tissues or low expression groups was evaluated on Expression differences, prognostic value, and correlations with tumor microenvironment. ADIPOR1 and ADIPOR2 genes are dysregulated in most cancers and display significant associations with cancer stemness, tumor immune microenvironment, immune checkpoint genes, and drug sensitivity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: