Key result
Asymptomatic treated hypopituitarism is linked to ~20% lower carotid distensibility versus controls.
Why the study?
There are limited data on the atherosclerotic process and early vascular changes in hypopituitary adults on conventional replacement therapy despite increased vascular mortality.
Does hypopituitarism on conventional replacement therapy increase carotid arterial stiffness in asymptomatic adults compared to matched controls?
Comparison
Hypopituitary adults on replacement therapy vs age- and sex-matched controls
Design
Case-control study using high-resolution ultrasonic imaging
Authors
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May indicate early atherosclerosis in treated hypopituitarism; leaves open causal contribution to vascular mortality and requires prospective confirmation.
Case-Control (n=73)
Does hypopituitarism on conventional replacement therapy increase carotid arterial stiffness in asymptomatic adults compared to matched controls?
Absolute Event Rate: 24.2% vs 30.1%
p-value: p=<0.05
Asymptomatic hypopituitary adults, particularly women, exhibit increased stiffness of the common carotid arteries, suggesting early premature atherosclerosis.
Markussis et al. (1997) conducted a case-control in Hypopituitarism (n=73). Hypopituitarism on conventional replacement therapy vs. Age- and sex-matched controls was evaluated on Common carotid artery distensibility coefficient (DC) (p=<0.05). Asymptomatic hypopituitary adults on replacement therapy had a significantly lower carotid distensibility coefficient compared to controls (24.2 vs 30.1 10(-3) kPa-1, P<0.05).
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