Key result
Expiratory threshold loading reduces submaximal exercise SV and CO in healthy and HF dogs.
Why the study?
The effects of augmented expiratory intrathoracic pressure on cardiac output and blood flow distribution during submaximal exercise in health and chronic heart failure were not well defined.
Does expiratory threshold loading impair cardiovascular function in healthy dogs and dogs with chronic heart failure during submaximal exercise?
Population
Healthy dogs and dogs with chronic heart failure induced by 6 weeks of rapid cardiac pacing
Comparison
Application of 5, 10, or 15 cmH2O expiratory threshold loads vs control expiratory intrathoracic pressure excursion
Design
Preclinical experimental study
Authors
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May impair exercise hemodynamics in HF models; hypothesis-generating for human translation.
Does expiratory threshold loading impair cardiovascular function in healthy dogs and dogs with chronic heart failure during submaximal exercise?
p-value: p=<0.05
Increases in expiratory intrathoracic pressure production reduce cardiac output and hindlimb blood flow during submaximal exercise in both healthy and heart failure models.
Miller et al. (2006) studied Healthy and chronic heart failure. Expiratory threshold loading vs. Nonloaded breathing was evaluated on Cardiac output and stroke volume (p=<0.05). Expiratory threshold loading significantly reduced stroke volume and cardiac output in both healthy dogs and dogs with chronic heart failure during submaximal exercise (P<0.05).
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