Key result
Chronic outpatient clopidogrel is linked to lower platelet reactivity versus acute inpatient use.
Why the study?
The stability of clopidogrel platelet reactivity over time after treatment initiation was not well characterized.
Does the duration and setting of clopidogrel treatment (chronic outpatient vs acute inpatient) affect platelet reactivity units and percent inhibition?
Observational (n=260)
Does the duration and setting of clopidogrel treatment (chronic outpatient vs acute inpatient) affect platelet reactivity units and percent inhibition?
Platelet reactivity and inhibition in response to clopidogrel evolve over time, demonstrating significant differences between acute inpatient and chronic outpatient settings.
Answers are grounded in this paper and cite their sources.
Platelet reactivity differs by clopidogrel setting; hypothesis-generating for time-dependent effects but should not yet change practice.
Platelet function testing is an important laboratory measure in clopidogrel treatment. We sought to investigate the stability of the reactivity of clopidogrel after 1 month of treatment. A prospective analysis was carried out using a matched study design to compare platelet reactivity units (PRUs) and platelet inhibition in clopidogrel-treated patients. Patients with various cardiac diseases were divided into 2 matched groups. The first group was treated on an inpatient acute basis, and the other group was treated on an outpatient chronic basis. PRU was measured 5 days after clopidogrel administration in the acute group and 1 month after chronic use for several cardiac indications in the second group. VerifyNow (Accumetrics) was used to detect platelet reactivity and calculate inhibition rates in response to clopidogrel. A total of 260 Saudi patients were enrolled, including 90 inpatients and 170 outpatients. A significant difference was observed in PRU (173.69 vs. 195) and percent inhibition (24.05% vs. 16.13%) between the outpatient and inpatient groups. Platelet function evolves over time and initial readings may not be constant.
No takes yet. Share an insight, caveat, or question.
Khalaf et al. (2015) conducted an observational in various cardiac diseases (n=260). Chronic outpatient clopidogrel treatment vs. Acute inpatient clopidogrel treatment was evaluated on Platelet reactivity units (PRU). Chronic outpatient clopidogrel use showed different platelet reactivity units and percent inhibition compared to acute inpatient use.
Synapse has enriched 10 related papers. Consider them for comparative context: