Key result
Higher serum resistin linked to greater carotid IMT and reduced arterial elasticity in male smokers.
Why the study?
The association between serum resistin levels and early atherosclerosis in male smokers was investigated to clarify its potential as an independent predictor.
Is serum resistin associated with subclinical atherosclerosis indices in male smokers?
Cross-Sectional (n=50)
Is serum resistin associated with subclinical atherosclerosis indices in male smokers?
Serum resistin concentration is independently associated with early atherosclerosis markers in male smokers, suggesting its potential as a biomarker for subclinical cardiovascular disease.
Answers are grounded in this paper and cite their sources.
Resistin testing adds no clinical value in male smokers now; leaves open its biomarker role pending larger prospective validation.
To investigate whether resistin is associated with early atherosclerosis in male smokers. The present study consecutively enrolled 50 male smokers. Their serum resistin contents were detected with enzyme linked immunosorbent assay (ELISA), and subclinical atherosclerosis indices, including carotid inner middle thickness (IMT) and arterial elasticity indices (C1 and C2), were measured. The association between serum resistin levels and IMT, C1 and C2 were respectively evaluated with the Pearson's correlation coefficient method. The results showed that the serum resistin level had a positive association with IMT (r = 0.307, p = .030), but were both inversely associated with C1 (r = -0.440, p = .001) and C2 (r = -0.381, p = .006). These associations remained significant even after adjustment for cardiovascular confounders. In conclusion, serum resistin concentration was independently associated with early atherosclerosis in male smokers.
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He et al. (2016) conducted a cross-sectional in Subclinical atherosclerosis (n=50). Serum resistin levels was evaluated on Carotid inner middle thickness (IMT) (r = 0.307, p=0.030). Serum resistin levels were positively associated with carotid IMT (r=0.307, p=0.030) and inversely associated with arterial elasticity indices C1 and C2 in male smokers.
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