June 1, 2005SLEEP
Autonomic Dysfunction in Children with Sleep-Disordered Breathing
Key result
Childhood sleep-disordered breathing is linked to ~15% greater sympathetic vascular reactivity during sigh maneuvers.
- P<.0001
- n=57
Why the study?
Sympathetic responses in children with and without sleep-disordered breathing were not well characterized.
Does sleep-disordered breathing increase sympathetic vascular reactivity in children?
Comparison
Children with sleep-disordered breathing (apnea-hypopnea index >5) vs controls (apnea-hypopnea index <1)
Design
Prospective observational study
Authors
Discussion
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Implication
May indicate early autonomic dysregulation in children with sleep-disordered breathing; leaves open whether this predicts cardiovascular outcomes.
Study Design
Type
Observational (n=57)
Multicenter
No
Structured PICO
Does sleep-disordered breathing increase sympathetic vascular reactivity in children?
P
Population
57 children undergoing overnight polysomnographic assessments, categorized into sleep-disordered breathing (AHI > 5) or controls (AHI < 1).
C
Comparator
Children without sleep-disordered breathing (apnea-hypopnea index <1)
O
Outcome
Changes in sympathetic activity following vital capacity sighs, assessed by average maximal pulse arterial tonometry signal attenuationsurrogate
Main Result
Absolute Event Rate: 74.1% vs 59.2%
p-value: p=<.0001
Children with sleep-disordered breathing exhibit altered autonomic nervous system regulation with increased sympathetic vascular reactivity during wakefulness.
Cite This Study
O’Brien et al. (2005) conducted an observational in Sleep-disordered breathing (n=57). Sleep-disordered breathing vs. Without sleep-disordered breathing (controls) was evaluated on Sympathetic discharge-induced attenuation of pulse arterial tonometry signal during sigh maneuvers (p=<.0001). Children with sleep-disordered breathing had significantly increased sympathetic vascular reactivity during sigh maneuvers compared to controls (74.1% vs 59.2% signal attenuation; P<.0001).