Key result
iPSC reprogramming generates renewable human beige adipocytes with enhanced thermogenic and anti-diabetic potential.
Why the study?
Beige adipocytes convert energy to heat and represent a therapeutic target for obesity-associated metabolic syndrome, but a renewable human source was lacking.
A novel method to generate human beige adipocytes from iPSCs provides a renewable resource for studying beige adipogenesis and developing cellular therapies for metabolic syndrome.
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iPSC-derived beige adipocytes now enable human thermogenesis studies; leaves open therapeutic translation for obesity.
Su et al. (2018) studied Metabolic syndrome. Generation of human beige adipocytes from induced pluripotent stem cells (iPSCs) was evaluated on Generation of thermogenically active beige adipocytes. A robust method was developed to generate a renewable source of human beige adipocytes from induced pluripotent stem cells with increased thermogenic function and anti-diabetic secretion potential.
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