What is the clinical evidence from this study?

Study design: Case Report. Population: Inclusion Body Hepatitis (IBH) (n=64000). Intervention: FAdV-8b infection vs. Less affected flocks. Primary outcome: Cumulative mortality.

What does this research mean for the field?

FAdV-8b infection causes outbreaks of Inclusion Body Hepatitis in commercial broilers, leading to high mortality, characteristic clinicopathological lesions, and impaired production performance. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 25, 2022Veterinary SciencesOpen Access

First Detection and Identification of FAdV-8b as the Causative Agent of an Outbreak of Inclusion Body Hepatitis in a Commercial Broiler Farm in Greece

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Key result

FAdV-8b infection linked to ~17% mortality in a broiler flock inclusion body hepatitis outbreak.

n=64,000

Why the study?

The increased number of IBH cases, virulence of isolate strains, and lack of cross-species protection highlight the need for detailed in-field data to develop control strategies.

Population

64,000 broiler chickens in a commercial farm in Macedonia, Greece

Comparison

Flock A with higher mortality vs Flocks B and C with lower mortality

Design

Case report with clinicopathological and molecular investigation

Authors

VTVasilios TsiourisAristotle University of Thessaloniki TMTilemachos MantziosAristotle University of Thessaloniki KKKonstantinos KiskinisAristotle University of Thessaloniki

Discussion

Member takes

Implication

Alerts to atypical IBH in commercial poultry; leaves open strain-specific vaccine needs.

Study Design

Type

Case Report (n=64,000)

Multicenter

Structured PICO

Population

64,000 commercial broiler chickens in Greece experiencing an outbreak of Inclusion Body Hepatitis caused by FAdV-8b.

Outcome

Detection and identification of the causative agent of the Inclusion Body Hepatitis outbreak

Main Result

Absolute Event Rate: 17.4% vs 2.9%

This is the first report of the detection and identification of FAdV-8b associated with Inclusion Body Hepatitis in commercial broiler flocks in Greece.

Limitations

Lack of information about circulating FAdV serotypes in the country
Exact route of horizontal transmission could not be determined
Lack of information about the circulating FAdV serotypes in the country

Cite This Study

Tsiouris et al. (2022) conducted a case report in Inclusion Body Hepatitis (IBH) (n=64,000). FAdV-8b infection vs. Less affected flocks was evaluated on Cumulative mortality. FAdV-8b infection caused an outbreak of Inclusion Body Hepatitis in a commercial broiler farm, resulting in up to 17.4% cumulative mortality in the most severely affected flock.

synapsesocial.com/papers/6aab8432091e7e060ee9d176 https://doi.org/10.3390/vetsci9040160

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First Detection and Identification of FAdV-8b as the Causative Agent of an Outbreak of Inclusion Body Hepatitis in a Commercial Broiler Farm in Greece

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

First Detection and Identification of FAdV-8b as the Causative Agent of an Outbreak of Inclusion Body Hepatitis in a Commercial Broiler Farm in Greece

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider