Key result
Finger PAT reveals ~35% lower reactive hyperemia pulse wave amplitude in high-risk versus low-risk CAD men.
Why the study?
Coronary artery disease risk is not fully revealed by traditional risk factors, and a simple noninvasive tool for detecting high-risk patients applicable in large populations is needed.
Does peripheral arterial tonometry (PAT) correlate with residual risk status in men with stable CAD and well-controlled LDL-C?
Population
42 men with stable CAD and well-controlled LDL-C levels
Comparison
Peripheral arterial tonometry measurement across high-risk, moderate-risk, and low-risk groups defined by hs-CRP and Lp-PLA2 levels
Design
Observational study measuring microvascular endothelial function with finger PAT
Authors
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PAT may flag residual risk in stable CAD men; leaves open prospective validation before clinical adoption.
Observational (n=42)
Does peripheral arterial tonometry (PAT) correlate with residual risk status in men with stable CAD and well-controlled LDL-C?
Absolute Event Rate: 1.3% vs 2%
p-value: p=<0.05
Peripheral arterial tonometry may serve as a simple, noninvasive tool to identify high residual risk in men with stable CAD despite well-controlled LDL-C.
Heffernan et al. (2010) conducted an observational in Coronary Artery Disease (n=42). High-risk status (elevated hs-CRP and Lp-PLA2) vs. Low-risk status (low hs-CRP and Lp-PLA2) was evaluated on Pulse wave amplitude during reactive hyperemia (PWA-RH) (p=<0.05). Pulse wave amplitude during reactive hyperemia measured by peripheral arterial tonometry was significantly lower in high-risk men with CAD (1.3) compared to low-risk men (2.0) (P<0.05).
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