Key result
CAD risk factors linked to ~27% lower peripheral vascular response to exercise vs healthy controls.
Why the study?
Abnormal coronary and brachial artery responses have been described in individuals with risk factors for coronary artery disease, but peripheral vascular response to exercise using peripheral arterial tonometry has not been assessed.
Does peripheral arterial tonometry during exercise detect impaired peripheral vascular response in patients with CAD risk factors compared to healthy controls?
Observational (n=60)
Does peripheral arterial tonometry during exercise detect impaired peripheral vascular response in patients with CAD risk factors compared to healthy controls?
Absolute Event Rate: 83% vs 114%
p-value: p=< 0.01
Peripheral arterial tonometry during exercise reveals an impaired systemic vascular response in individuals with CAD risk factors, suggesting its potential utility as a simple technique for assessing endothelial function.
Exercise PAT may identify endothelial impairment in CAD risk patients; leaves open clinical utility pending prospective validation.
BACKGROUND: Abnormal coronary and brachial artery responses have been described in individuals with risk factors for coronary artery disease (CAD). Peripheral arterial tonometry (PAT), a newly developed digital plethysmographic technique was used to assess peripheral vascular response to exercise in healthy controls and individuals with risk factors. METHODS AND RESULTS: Continuous finger PAT during Bruce protocol exercise test was performed in 30 subjects with risk factors for CAD and 30 healthy individuals. Compared with baseline, the PAT wave amplitude at peak exercise decreased in the subjects but increased in the controls: 83 +/- 28% vs. 114 +/- 40% respectively, p < 0.01. CONCLUSIONS: A different pattern of systemic vascular response to exercise was found in individuals with risk factors for atherosclerosis. Since the vascular behavior in these patients is probably related to endothelial dysfunction, it may be that peripheral arterial tonometry can be used as a simple, readily available technique to assess endothelial function.
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Chenzbraun et al. (2001) conducted an observational in Risk factors for coronary artery disease (n=60). Risk factors for coronary artery disease vs. Healthy controls was evaluated on Peripheral arterial tonometry (PAT) wave amplitude at peak exercise compared with baseline (p=< 0.01). Individuals with risk factors for coronary artery disease had an impaired peripheral vascular response to exercise compared to healthy controls (PAT wave amplitude 83% vs 114%; p<0.01).
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