Key result
Nicorandil cuts serum creatinine ~44% and decreases aortic calcification in adenine-induced nephropathy.
Why the study?
Vascular dysfunctions including endothelial dysfunction and vascular calcification are common in chronic kidney disease, and the protective effects of nicorandil on these dysfunctions in adenine-induced nephropathy were investigated.
Does nicorandil improve vascular and renal dysfunctions in a rat model of adenine-induced nephropathy?
Does nicorandil improve vascular and renal dysfunctions in a rat model of adenine-induced nephropathy?
Absolute Event Rate: 1.05% vs 1.87%
p-value: p=<0.0001
Nicorandil shows potential protective effects against vascular and renal impairment in a rat model of adenine-induced nephropathy, likely through attenuation of vascular calcification and activation of Nrf2 and eNOS.
Hypothesis-generating in adenine-induced rat nephropathy; leaves open clinical translation pending human trials.
Vascular dysfunctions in chronic kidney disease (CKD) include endothelial dysfunctions and vascular calcification (VC). In the present study, we examined the possible protective effect of nicorandil (potassium channel opener) on renal and vascular dysfunctions in a rat model of adenine-induced nephropathy and its underlying mechanisms. Thirty-four male Sprague-Dawley rats were randomly allocated into 3 groups: Control group, Adenine group (animals received high-adenine diet for 4 weeks), and Nicorandil group (animals received adenine for 4 weeks and nicorandil 1 mg/kg per oral for 4 weeks). The results showed significant reduction in the body weight, heart rate (HR), hemoglobin contents, serum Ca2+ and reduction in the expression of mRNA of endothelial nitric oxide synthase (eNOS) and nuclear factor erythroid related factor 2 (nrf2) genes in aortic tissues with significant increase in arterial blood pressure (ABP), serum creatinine, blood urea nitrogen (BUN), plasma renin activity (PRA), K+ and phosphate (PO43-), urinary albumin excretion (UAE) and aortic VC in Adenine group compared to normal group (p < 0.05). On the other hand, coadminsitration of nicorandil caused significant improvement in the studied parameters compared to Adenine group (p < 0.05). We concluded that nicorandil has a potential protective effect against the vascular and renal impairment induced by adenine, which might be due to attenuation of vascular calcifications, activation of Nrf2 and eNOS genes in aortic tissues.
No takes yet. Share an insight, caveat, or question.
Hussein et al. (2019) studied Adenine-induced nephropathy (n=34). Nicorandil vs. Adenine alone (high-adenine diet) was evaluated on Serum creatinine (mg/dl) (p=<0.0001). Nicorandil significantly attenuated vascular and renal impairment in adenine-induced nephropathy, reducing serum creatinine from 1.87 to 1.05 mg/dl and decreasing aortic vascular calcification.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: