August 13, 2002Neurology
Amiodarone and acetazolamide for the treatment of genetically confirmed severe Andersen syndrome
Key result
Amiodarone and acetazolamide achieve sustained remission in a severe case of Andersen syndrome.
- n=1
Why the study?
Therapeutic options for life-threatening cardiac dysrhythmias in Andersen syndrome are limited.
Does treatment with amiodarone and acetazolamide improve symptoms and prevent arrhythmias in a patient with severe Andersen syndrome?
Population
One severely affected 18-year-old woman with genetically confirmed severe Andersen syndrome
Comparison
Treatment with amiodarone and acetazolamide
Design
Case report
Authors
Discussion
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Member takes
Implication
May support amiodarone-acetazolamide in refractory Andersen syndrome; hypothesis-generating case report leaves open need for controlled trials.
Study Design
Type
Case Report (n=1)
Structured PICO
Does treatment with amiodarone and acetazolamide improve symptoms and prevent arrhythmias in a patient with severe Andersen syndrome?
P
Population
One 18-year-old woman with genetically confirmed severe Andersen syndrome.
I
Intervention
Amiodarone and acetazolamide
O
Outcome
Sustained remission of symptoms and arrhythmias
Amiodarone and acetazolamide may be an effective therapeutic option for managing life-threatening ventricular tachyarrhythmias and periodic paralysis in severe Andersen syndrome.
Cite This Study
Junker et al. (2002) conducted a case report in Andersen syndrome (n=1). Amiodarone and acetazolamide was evaluated on Sustained remission. Treatment with amiodarone and acetazolamide resulted in sustained remission in a severely affected 18-year-old woman with genetically confirmed Andersen syndrome.