Key result
Propafenone plus beta-blockers suppresses bidirectional VT and reverses tachycardiomyopathy in an Andersen-Tawil syndrome case.
Why the study?
Bidirectional ventricular tachycardia is a rare ECG finding associated with hereditary channelopathies, requiring early recognition and targeted genetic investigation to prevent arrhythmia-induced cardiomyopathy.
Comparison
Propafenone and beta-blocker therapy
Design
Case report
Authors
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Identifies bidirectional VT via family screening in asymptomatic child with KCNJ2 variant; extends phenotype but leaves open systematic evaluation.
Case Report (n=1)
Propafenone combined with a beta-blocker may be an effective therapeutic alternative for suppressing bidirectional ventricular tachycardia and reversing tachycardiomyopathy in Andersen-Tawil syndrome when flecainide is unavailable.
Assunção et al. (2026) conducted a case report in Andersen-Tawil syndrome with bidirectional ventricular tachycardia (n=1). Propafenone and beta-blocker therapy was evaluated on Arrhythmic burden and ventricular remodeling. In an 11-year-old girl with Andersen-Tawil syndrome, the combination of propafenone and beta-blocker therapy suppressed bidirectional ventricular tachycardia and reversed tachycardiomyopathy.
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