Key result
Glyburide improves myocardial function and energy metabolism in diabetic rats by shifting myosin to active V1.
Why the study?
The effects of chronic sulfonylurea treatment on myocardial metabolism and function in insulin-dependent diabetic rats were not fully understood.
Does glyburide improve myocardial mechanical function and energy metabolism in streptozocin-induced diabetic rats?
Population
Adult rats with insulin-dependent diabetes induced by high doses of streptozocin
Comparison
Sulfonylurea glyburide treatment vs untreated diabetic rats
Design
Preclinical experimental study
Authors
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Hypothesis-generating in diabetic rat models; should not change clinical practice pending human data.
Does glyburide improve myocardial mechanical function and energy metabolism in streptozocin-induced diabetic rats?
In a diabetic rat model, glyburide therapy provided myocardial benefits by improving energy metabolism and mechanical function.
Mozaffari et al. (1988) studied Insulin-dependent diabetes. Glyburide vs. Untreated diabetic rats was evaluated on Myocardial glucose utilization, mechanical function, and myosin ATPase activity. Glyburide therapy in streptozocin-induced diabetic rats improved myocardial mechanical function, energy metabolism, and promoted a shift in myosin towards the most active V1 form.
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