Key result
Tolbutamide exposure in isolated diabetic rat hearts stimulated mechanical function independent of preload and mobilized glycogen significantly more than in nondiabetic hearts.
Why the study?
Does tolbutamide alter myocardial metabolism and mechanical performance in isolated diabetic rat hearts?
Population
Isolated, glucose-perfused rat hearts (diabetic and nondiabetic models)
Comparison
Buffer containing 0.4 mM tolbutamide vs Nondiabetic rat hearts exposed to tolbutamide…
Design
Preclinical
Authors
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Tolbutamide may enhance myocardial function via glycogenolysis in diabetic hearts; leaves open translation to human therapy.
Does tolbutamide alter myocardial metabolism and mechanical performance in isolated diabetic rat hearts?
Tolbutamide directly alters myocardial metabolism and mechanical performance in diabetic rat hearts by stimulating glycogenolysis, independent of insulin action.
Tan et al. (1984) studied Diabetic rat hearts. Tolbutamide vs. Nondiabetic rat hearts was evaluated on Energy metabolism and myocardial contractility. Tolbutamide exposure in isolated diabetic rat hearts stimulated mechanical function independent of preload and mobilized glycogen significantly more than in nondiabetic hearts.
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