January 1, 1991Japanese Heart JournalOpen Access

Chronic Effects of Tolbutamide on Myocardial Tension during Ischemia and Reperfusion in Perfused Hearts Isolated from Insulin Dependent and Non Insulin Dependent Diabetic Rats.

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Why the study?

Does chronic tolbutamide administration improve myocardial contractility during ischemia and reperfusion in diabetic rat hearts?

Population

Male Sprague-Dawley rats with insulin-dependent diabetes or non-insulin-dependent diabetes, and non-diabetic…

Comparison

Tolbutamide 100 mg/kg/day via orogastric tube… vs Untreated IDDM and NIDDM rats, and non-diabetic…

Design

Preclinical

Follow-up

6 weeks

Authors

KOKoichi OshiroUniversity of the Ryukyus KMKeiji MurakamiKawasaki University of Medical Welfare RSRyuji SunagawaUniversity of the Ryukyus

Discussion

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Implication

May improve contractility in diabetic rat ischemia-reperfusion models; hypothesis-generating, should not yet change practice.

Structured PICO

Does chronic tolbutamide administration improve myocardial contractility during ischemia and reperfusion in diabetic rat hearts?

Population

Male Sprague-Dawley rats with insulin-dependent diabetes (IDDM, STZ-induced) or non-insulin-dependent diabetes (NIDDM, STZ-induced in neonates), and non-diabetic controls.

Intervention

Tolbutamide 100 mg/kg/day via orogastric tube for 6 weeks.

Comparator

Untreated IDDM and NIDDM rats, and non-diabetic controls.

Outcome

Myocardial contractility parameters (myocardial developed tension [T], contraction velocity [+dT/dt], relaxation velocity [-dT/dt], and resting tension [RT]) during 15 min global ischemia and 20 min reperfusion in isolated Langendorff perfused hearts.surrogate

Chronic tolbutamide administration improves myocardial contractility during ischemia and reperfusion in diabetic rat models, independent of glycemic control.

Cite This Study

Oshiro et al. (1991) studied this question.

synapsesocial.com/papers/6a7239aaac440176ef2a92ea https://doi.org/10.1536/ihj.32.347

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Chronic Effects of Tolbutamide on Myocardial Tension during Ischemia and Reperfusion in Perfused Hearts Isolated from Insulin Dependent and Non Insulin Dependent Diabetic Rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Chronic Effects of Tolbutamide on Myocardial Tension during Ischemia and Reperfusion in Perfused Hearts Isolated from Insulin Dependent and Non Insulin Dependent Diabetic Rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider