Why the study?
Does intravenous tolbutamide improve inotropic response in nondiabetic subjects during cardiac catheterization?
Population
15 nondiabetic subjects undergoing diagnostic cardiac catheterization
Comparison
Tolbutamide 250 mg intravenous bolus injection vs Baseline/control values prior to injection
Design
Cohort
Follow-up
30 minutes
Authors
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IV tolbutamide linked to transient inotropy in nondiabetics; hypothesis-generating and should not yet change practice.
Does intravenous tolbutamide improve inotropic response in nondiabetic subjects during cardiac catheterization?
Intravenous tolbutamide exerts a small but measurable transient positive inotropic effect on the human myocardium.
Hildner et al. (1975) studied this question.
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