Why the study?
Does glyburide or tolbutamide affect myocardial function in normal male volunteers?
Does glyburide or tolbutamide affect myocardial function in normal male volunteers?
Glyburide, unlike tolbutamide, increases myocardial contractility as measured by ejection fraction in normal human subjects.
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Should not alter sulfonylurea use based on healthy-volunteer data; leaves open differential effects on myocardial contractility in patients.
Rothschild et al. (1989) studied this question.
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