Key result
Intravenous tolbutamide and glibornuride produced no significant changes in systolic time intervals, heart rate, or blood pressure, indicating no acute positive inotropic action.
Why the study?
Do intravenous tolbutamide and glibornuride affect systolic time intervals in healthy volunteers?
Do intravenous tolbutamide and glibornuride affect systolic time intervals in healthy volunteers?
Intravenous tolbutamide and glibornuride do not exhibit acute positive inotropic action in healthy volunteers.
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No acute inotropic effects seen in healthy volunteers; leaves open any chronic cardiac actions in diabetes.
Dubach et al. (2008) studied Healthy volunteers (n=5). Intravenous tolbutamide and glibornuride was evaluated on Systolic time intervals (QS2c, LVETc, PEPc and PEP/LVET). Intravenous tolbutamide and glibornuride produced no significant changes in systolic time intervals, heart rate, or blood pressure, indicating no acute positive inotropic action.
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