Key result
Targeted ultrasound contrast agents improve ischemic signal enhancement and maintain it post-reperfusion in animal models.
Why the study?
There is a need to categorize targeted ultrasound contrast agents used in detecting myocardial ischemia and to identify gaps such as lack of comparative studies among molecular markers and versus standard care.
Do targeted ultrasound contrast agents improve the detection of myocardial ischemia in animal models?
Systematic Review (n=14)
Do targeted ultrasound contrast agents improve the detection of myocardial ischemia in animal models?
Targeted ultrasound contrast agents show promise in preclinical models for enhancing the detection of myocardial ischemia, highlighting a need for further comparative studies.
May improve ischemia detection in animal models; extends preclinical data but leaves open clinical translation.
Objective: A systematic search was conducted to categorize targeted ultrasound contrast agents used in the detection of myocardial ischemia. Methods: The search identified 14 primary research articles published from 2000 to August 2019 that fulfilled the selection criteria. All studies were conducted in animal models ranging from mice to rhesus monkeys, with the most common targets being P-selectin and E-selectin. Results: These studies show that targeted ultrasound contrast agents produced greater signal enhancement in regions with prolonged ischemia and maintained enhancement hours after reperfusion. Conclusion: This review identified gaps in the literature, such as a need for comparative studies among different molecular markers and between current standard of care with the use of targeted contrast agents in cardiac ultrasound.
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Lau et al. (2020) conducted a systematic review in Myocardial ischemia (n=14). Targeted ultrasound contrast agents was evaluated on Signal enhancement. Targeted ultrasound contrast agents produced greater signal enhancement in regions with prolonged ischemia and maintained enhancement hours after reperfusion in animal models.
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