What is the clinical evidence from this study?

Study design: RCT. Population: healthy volunteers (n=31). Intervention: Sotalol vs. Propranolol and placebo. Primary outcome: QTc interval at rest (p=<0.01).

What does this research mean for the field?

Sotalol prolongs ventricular repolarization at rest compared to placebo, but this class III antiarrhythmic effect is progressively attenuated during physiological exercise. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 3, 2005Journal of Zhejiang University. Science AOpen Access

The effects of sotalol on ventricular repolarization during exercise

Q: What are the key findings of this study?

Sotalol significantly prolonged QTc intervals at rest compared to placebo (324.86 ms vs 314.06 ms, P<0.01), but its delay of ventricular repolarization was attenuated during exercise.

Q: What does this research mean for the field?

Sotalol prolongs ventricular repolarization at rest compared to placebo, but this class III antiarrhythmic effect is progressively attenuated during physiological exercise. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Sotalol prolongs resting QTc by ~11 ms versus placebo, but this effect attenuates during exercise.

P<0.01
n=31

Authors

JLJian LiINTI International University

Discussion

Member takes

Implication

Sotalol's class III effect on repolarization may attenuate during exercise; leaves open clinical relevance in active patients and warrants targeted trials.

Study Design

Type

RCT (n=31)

Randomization

randomized

PICO

Population

31 healthy volunteers who underwent a maximal treadmill exercise test after random treatment with sotalol, propranolol, and placebo.

Intervention / Comparator

Sotalol vs Propranolol and placebo

Primary Outcome

QTc interval at rest, p=<0.01

Main Result

Absolute Event Rate: 324.86% vs 314.06%

p-value: p=<0.01

Cite This Study

Jian Li (2005) conducted an RCT in healthy volunteers (n=31). Sotalol vs. Propranolol and placebo was evaluated on QTc interval at rest (p=<0.01). Sotalol significantly prolonged QTc intervals at rest compared to placebo (324.86 ms vs 314.06 ms, P<0.01), but its delay of ventricular repolarization was attenuated during exercise.

synapsesocial.com/papers/6aab9bb8083100ccc151eecd https://doi.org/10.1631/jzus.2005.b0249

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Implication

Sotalol's class III effect on repolarization may attenuate during exercise; leaves open clinical relevance in active patients and warrants targeted trials.

The effects of sotalol on ventricular repolarization during exercise

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Cite This Study

The effects of sotalol on ventricular repolarization during exercise

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Cite This Study

Also Consider

Also Consider