Why the study?
Does intravenous sotalol alter atrial action potential duration and refractoriness in patients with paroxysmal supraventricular atrial arrhythmias?
Does intravenous sotalol alter atrial action potential duration and refractoriness in patients with paroxysmal supraventricular atrial arrhythmias?
Intravenous sotalol prolongs atrial action potential duration and refractoriness in a cycle-length dependent manner without increasing regional repolarization inhomogeneity.
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May inform sotalol mechanism in one case; leaves open clinical translation to arrhythmia suppression.
Hayward et al. (1986) studied this question.
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