Key result
Sotalol preserved its Class III antiarrhythmic effects even in partially depolarized rabbit papillary muscle fibers where rapid inward current is depressed by elevated potassium.
Population
Rabbit right ventricular papillary muscles studied in vitro
Comparison
Sotalol (10 mol/L) in elevated extracellular… vs Atenolol (10 mol/L) in elevated extracellular…
Design
Preclinical
Authors
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Offers preclinical support for sotalol in hyperkalemia; leaves open translation to human arrhythmias.
The Class III antiarrhythmic effects of sotalol are preserved even in partially depolarized cardiac fibers under hyperkalemic conditions.
Cobbe et al. (1985) studied this question. Sotalol vs. Atenolol was evaluated on Action potential duration and effective refractory period. Sotalol preserved its Class III antiarrhythmic effects even in partially depolarized rabbit papillary muscle fibers where rapid inward current is depressed by elevated potassium.
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