Key result
In rabbit papillary muscles, the class III effect of sotalol was preserved under mild hypoxia (APD90 249 vs 138 ms, p<0.001) but abolished under severely hypoxic, glucose-free conditions.
Why the study?
Does sotalol maintain its class III antiarrhythmic properties (APD prolongation) under conditions of hypoxia, substrate depletion, acidosis, and hyperkalaemia in rabbit papillary muscles?
Population
Rabbit papillary muscles
Comparison
dl-sotalol 10 mol/L under varying conditions of… vs Control conditions without sotalol
Design
Preclinical
Follow-up
30 minutes
Authors
Loading...
Sotalol class III effect may fail in severe ischemia; hypothesis-generating for antiarrhythmic use in hypoxic myocardium, needs in vivo confirmation.
Does sotalol maintain its class III antiarrhythmic properties (APD prolongation) under conditions of hypoxia, substrate depletion, acidosis, and hyperkalaemia in rabbit papillary muscles?
Absolute Event Rate: 249% vs 138%
p-value: p=<0.001
The class III antiarrhythmic effect of sotalol is preserved during mild hypoxia but lost under severe hypoxic and ischemic-like conditions in vitro.
Cobbe et al. (1985) studied this question. dl-sotalol vs. control was evaluated on Action potential duration (APD90) under mild hypoxia (p=<0.001). In rabbit papillary muscles, the class III effect of sotalol was preserved under mild hypoxia (APD90 249 vs 138 ms, p<0.001) but abolished under severely hypoxic, glucose-free conditions.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: