Key result
Sotalol reduced ventricular arrhythmias during myocardial ischaemia and reperfusion, though its electrophysiological effects on normal myocardium poorly predicted its mechanism in ischaemic tissue.
Why the study?
Does sotalol reduce arrhythmias and alter electrophysiology during myocardial ischaemia and reperfusion in isolated guinea pig hearts?
Population
Isolated, buffer perfused guinea pig hearts subjected to 30 min of myocardial ischaemia and subsequent…
Comparison
Sotalol 10(-4) mol X litre-1 vs Control (untreated ischaemic/reperfused hearts)
Design
Preclinical
Follow-up
30 min of ischaemia and subsequent reperfusion
Authors
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Sotalol's antiarrhythmic effect in guinea pig ischaemia-reperfusion warrants no clinical change; leaves open mechanism and translation to human tissue.
Does sotalol reduce arrhythmias and alter electrophysiology during myocardial ischaemia and reperfusion in isolated guinea pig hearts?
Sotalol reduces ventricular arrhythmias during ischaemia and reperfusion in guinea pig hearts, but its electrophysiological effects in normal tissue do not predict its mechanism in ischaemic tissue.
Culling et al. (1984) studied Myocardial ischaemia and reperfusion. Sotalol vs. Control was evaluated on Incidence of ventricular arrhythmias and electrophysiological changes. Sotalol reduced ventricular arrhythmias during myocardial ischaemia and reperfusion, though its electrophysiological effects on normal myocardium poorly predicted its mechanism in ischaemic tissue.
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