Why the study?
Does d-sotalol attenuate ischemia-induced action potential shortening in a pig model of reversible myocardial ischemia?
Population
25 anesthetized pigs in a model of low-flow posterior wall myocardial ischemia
Comparison
d-sotalol infusion during myocardial ischemia vs Myocardial ischemia without d-sotalol
Design
Preclinical
Authors
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May lessen repolarization dispersion in ischemia; leaves open translation to human arrhythmia prevention or calcium-related risks.
Does d-sotalol attenuate ischemia-induced action potential shortening in a pig model of reversible myocardial ischemia?
d-Sotalol attenuates ischemia-induced action potential shortening in a pig model, which may decrease dispersion of repolarization but could theoretically favor calcium overload.
O’Hara et al. (2000) studied this question.
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