What question did this study set out to answer?

To calculate 30-year absolute risk estimates for colorectal cancer based on healthy lifestyle factors, polygenic risk scores, and colonoscopy history.

March 13, 2020GastroenterologyOpen Access

Estimation of Absolute Risk of Colorectal Cancer Based on Healthy Lifestyle, Genetic Risk, and Colonoscopy Status in a Population-Based Study

View Full Paper

Ask AI

Bookmark

Authors

PCPrudence R. CarrGerman Cancer Research Center KWKorbinian WeiglIFT Institut für Therapieforschung DEDominic EdelmannGerman Cancer Research Center

Discussion

Member takes

Implication

Case-control study reveals absolute colorectal cancer risk drops with colonoscopy and healthy lifestyle across genetic profiles in adults, indicating substantial preventable disease burden.

Key Points

To calculate 30-year absolute risk estimates for colorectal cancer based on healthy lifestyle factors, polygenic risk scores, and colonoscopy history.
Analyzed data from 4,220 patients with colorectal cancer and 3,338 controls from a population-based case-control study in Germany (DACHS study, DRKS00011793).
Combined population registries with a healthy lifestyle score (evaluating smoking, alcohol, diet, activity, and adiposity), a 90-SNP polygenic risk score, and colonoscopy history within the preceding 10 years to model 30-year absolute risk.
For 50-year-olds without a colonoscopy in the past 10 years, 30-year absolute colorectal cancer risk ranged from 3.5% to 13.4% in men and 2.5% to 10.6% in women across genetic and lifestyle score strata.
For 50-year-olds with a colonoscopy in the past 10 years, 30-year absolute risk was markedly lower, ranging from 1.2% to 4.8% in men and 0.9% to 4.2% in women.
Adherence to a healthy lifestyle consistently decreased the 30-year absolute risk of colorectal cancer across all genetic risk profiles.

Cite This Study

Carr et al. (2020) studied this question.

synapsesocial.com/papers/6aab9c901bb6b918d8ca2dc7 https://doi.org/10.1053/j.gastro.2020.03.016

View Full Paper

Ask AI

Bookmark

Implication

Case-control study reveals absolute colorectal cancer risk drops with colonoscopy and healthy lifestyle across genetic profiles in adults, indicating substantial preventable disease burden.

Estimation of Absolute Risk of Colorectal Cancer Based on Healthy Lifestyle, Genetic Risk, and Colonoscopy Status in a Population-Based Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Estimation of Absolute Risk of Colorectal Cancer Based on Healthy Lifestyle, Genetic Risk, and Colonoscopy Status in a Population-Based Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider