Key result
NBTE presenting as recurrent stroke reveals an underlying early-stage breast carcinoma.
Why the study?
Cases presenting with NBTE leading to the diagnosis of malignancy are rarely reported, especially with early-stage breast carcinoma.
Case Report (n=1)
NBTE presenting as recurrent stroke can be the initial manifestation of early-stage breast carcinoma, highlighting the need to screen for malignancy in such cases.
Answers are grounded in this paper and cite their sources.
NBTE-linked recurrent stroke may signal occult breast cancer; single case leaves open whether screening improves outcomes.
We present a case of a 71-year-old woman with recurrent stroke episodes due to non-bacterial thrombotic endocarditis (NBTE) leading to the diagnosis of an early-stage breast carcinoma. NBTE is associated with a variety of inflammatory states, including malignancy. NBTE presents itself with systemic embolization, mostly stroke. Treatment consists of treating the underlying condition and start of systemic anticoagulation therapy. Cardiac surgery is restricted to highly selected cases, since prognosis usually is limited by the neoplasm, which usually is in an advanced stage at time of diagnosis of NBTE. The malignancy usually is diagnosed prior to NBTE. Cases presenting with NBTE leading to the diagnosis of malignancy, however, are rarely reported. To our knowledge, we present the first case leading to the diagnosis of an early-stage breast carcinoma.
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Detremerie et al. (2016) conducted a case report in Stroke due to non-bacterial thrombotic endocarditis and early-stage breast carcinoma (n=1). A 71-year-old woman presented with recurrent stroke episodes due to non-bacterial thrombotic endocarditis, which led to the rare diagnosis of an early-stage breast carcinoma.
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