Key result
Awareness of high genetic CAD risk is linked to increased self-reported heart health behaviors.
Why the study?
The impact of personalized risk reports including genetic and non-genetic risk factors for CAD on heart health behaviors was evaluated.
Does awareness of increased genetic risk for CAD improve self-reported heart health behaviors in CPMC participants?
Observational (n=683)
Does awareness of increased genetic risk for CAD improve self-reported heart health behaviors in CPMC participants?
Providing personalized genetic risk reports for CAD may motivate individuals to adopt healthier heart behaviors.
Answers are grounded in this paper and cite their sources.
May support genetic risk disclosure to promote heart-healthy behaviors; leaves open causal effects and need for randomized outcome trials.
Objective: The Coriell Personalized Medicine Collaborative (CPMC) research study is designed to evaluate the potential contributions of common genetic risk factors to complex disease prevention, screening, and management. Here we have focused on the impact of personalized risk reports including genetic and non-genetic risk factors for coronary artery disease (CAD) on heart health behaviors.Methods: We analyzed self-reported behavioral outcome data from 683 CPMC participants who received personalized CAD risk reports including: genetic risk, family history risk, and self-reported non-genetic risks based on smoking and diabetes status.Results: Participants with awareness of increased genetic risk for CAD were significantly more likely to report increases in heart health behaviors after viewing their personalized risk report (F-value=14.11, p-value=9.92 x 10−7). This result remained significant after controlling for BMI and gender (eta=0.58, p-value = 6.91 x 10−7).Conclusion: Our study indicates that individuals who are aware of their genetic risk for CAD may have higher motivation to increase heart health behaviors.
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Scheinfeldt et al. (2016) conducted an observational in Coronary artery disease risk (n=683). Awareness of increased genetic risk for CAD was evaluated on Self-reported increases in heart health behaviors (eta=0.58, p=6.91 x 10-7). Awareness of increased genetic risk for coronary artery disease was significantly associated with self-reported increases in heart health behaviors (p=6.91 x 10-7).
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