Key result
WHO class III/IV in pediatric PAH is linked to ~13% lower predicted 6MWD than class I/II.
Why the study?
The usefulness of the six-minute walk test in the management of children with pulmonary arterial hypertension and its correlation with clinical features was unclear.
Does the 6-minute walk test correlate with clinical status and biomarkers in children with pulmonary arterial hypertension?
Population
15 children aged 5 to 18 years with PAH confirmed by right heart catheterization
Comparison
6MWT parameters compared with NTproBNP, WHO-FC, echocardiography parameters, and treatment intensification events
Design
Observational study
Authors
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6MWD may support functional assessment in pediatric PAH; leaves open incremental value beyond echocardiography and need for prospective validation.
Observational (n=15)
No
Does the 6-minute walk test correlate with clinical status and biomarkers in children with pulmonary arterial hypertension?
Absolute Event Rate: 64.3% vs 77.5%
p-value: p=<0.01
The 6-minute walk test correlates with clinical status (WHO-FC, NTproBNP) and can provide additional information in the management of children with PAH.
Żuk et al. (2017) conducted an observational in Pulmonary Arterial Hypertension (n=15). WHO functional class III/IV vs. WHO functional class I/II was evaluated on 6-minute walk distance (% of predicted) (p=<0.01). In children with pulmonary arterial hypertension, patients in WHO functional class III/IV had a significantly lower 6-minute walk distance compared to those in class I/II (64.3% vs. 77.5%).
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