Key result
PCOS is linked to ~4-fold higher serum adiponectin and lower ghrelin versus healthy controls.
Why the study?
Polycystic ovarian syndrome is commonly accompanied by insulin resistance, and the study aimed to compare adiponectin and ghrelin levels between females with PCOS and healthy females and their association with insulin resistance.
Population
120 females; 60 with PCOS and 60 age-matched healthy controls
Comparison
Females with PCOS vs age-matched healthy females
Design
Case-control study
Authors
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Should not yet change PCOS management; hypothesis-generating for adipokine roles in metabolic risk.
Case-Control (n=120)
No
Absolute Event Rate: 19.64% vs 4.44%
p-value: p=0.019
Females with PCOS exhibit significantly higher adiponectin and lower ghrelin levels compared to healthy controls, which correlate with insulin resistance and lipid profile abnormalities.
Ali et al. (2022) conducted a case-control in Polycystic ovarian syndrome (n=120). Polycystic ovarian syndrome vs. Healthy controls was evaluated on Serum adiponectin level (µg/mL) (p=0.019). Females with polycystic ovarian syndrome had significantly higher serum adiponectin (19.64 vs 4.44 µg/mL) and lower ghrelin (16.54 vs 21.64 ng/mL) compared to healthy controls.
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