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Abstract 1,4‐Benzodiazepines bearing a carbon substituent at the 2‐position were obtained by reaction of 2‐chloromethylquinazoline 3‐oxides with stabilized carbanions. The carbanions of alkyl acetates, N,N‐disubstituted acetamides, acetonitrile, dimethylsulfone, N,N‐dimethyl methanesulfonamide and 2‐methylpyridine were successfully applied. The conversion of some of the 2‐carbon substituted 1,4‐benzodiazepines to imidazo[1,5‐a][1,4]benzodiazepines and [1,2,5]oxadiazino[5,4‐a][1,4]benzodiazepines is described.
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Walser et al. (1986) studied this question.
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